Precision Specimen Solutions Across Healthcare Disciplines
Clinical Laboratory Solutions
Engineering precise vacuum blood collection systems tailored for routine hematology, biochemistry, hemostasis, ESR, metabolic, and emergency diagnostics.
1. Complete Blood Count (CBC)
Important Handling Rule: Avoid freezing samples. For optimal diagnostic results, perform analysis promptly. If sample storage exceeds 24 hours, blood cell morphology and key hematological parameters will undergo alteration.
Designed for routine hematology testing, including complete blood count (CBC), blood cell morphology examination, and flow cytometry.
K2/K3 EDTA is uniformly spray-coated on the inner tube wall to ensure rapid, reliable anticoagulation and consistent sample preservation.
2. Serum Biochemistry
Suitable for a broad range of routine serum biochemistry, immunology, and therapeutic drug monitoring (TDM) applications.
For specimens requiring long-distance transport or delayed processing, Serum Separator Tubes (SST with gel) provide an effective barrier between serum and blood cells to maintain serum analyte integrity. Follow instruction guidelines after collection.
3. Coagulation Testing
Designed for routine and specialized hemostasis testing, including Prothrombin Time (PT), APTT, D-Dimer, and Fibrinogen assays.
Accurate blood fill volume and gentle immediate mixing (5-8 inversions) are strictly required to ensure the correct 9:1 blood-to-anticoagulant ratio for trustworthy results.
5. Glucose & Lactate Testing
Contains glycolytic inhibitors to stabilize blood glucose and lactate levels, preventing in vitro breakdown of glucose by erythrocytes.
Compatible with select instrument systems for dual HbA1c testing (verify reagent compatibility prior to use). Not recommended for enzyme activity testing.
6. Plasma Biochemistry & Emergency Testing
Heparin tubes provide anticoagulated plasma specimens for rapid plasma chemistry panels and emergency laboratory testing.
The heparin formulation maintains a stable plasma sample environment, allowing immediate centrifugation without waiting for blood clotting, supporting fast STAT turn-around times.
Clinical Laboratory Product Matrix
Comprehensive selection guide for routine blood collection tubes across biochemistry, hematology, coagulation, ESR, and emergency diagnostics.
Clinical Laboratory Collection Product Matrix
(No Additive tube) No Additive Red No Additive. Used for determinations in biochemistry, immunology and serology.
Minimum recommended clotting time: 60 minutes.
(Clot Activator tube) Clot Activator Red Used for preparing premium serum for determinations in biochemistry, immunology, trace element, serology and various types of virus detection.
Minimum recommended clotting time: 30 minutes.
(Gel and clot activator tube) Gel & Clot Activator Yellow Additive: Clot Activator | Accessory: Separating gel.
Used for preparing premium serum for determinations in biochemistry, immunology, trace element, virus detection and serology.
(K2/K3 EDTA tube) K2 / K3 EDTA Purple K2EDTA or K3EDTA.
Used for tests including hematology, PCR diagnostics and blood group research, widely used in clinical hematology.
(4NC sodium citrate tube) 3.8% Sodium Citrate Black Additive: 3.8% Sodium Citrate.
Used for Westergren sedimentation rate determination. Blood and sodium citrate volume ratio is 4:1.
(9NC sodium citrate tube) 3.2% / 3.8% Sodium Citrate Blue Used for tests including PT, APTT, Fg, TT, AT, FDP D-Dimer. Blood and sodium citrate volume ratio is 9:1.
Notice: PT tube is not recommended as the first tube to take blood.
(Sodium / Lithium heparin tube) Sodium / Lithium Heparin Green Additive: Sodium Heparin / Lithium Heparin.
Application: Hemorheology or emergency biochemistry diagnostics.
(Sodium Fluoride tube) Sodium Fluoride + EDTA Gray Additive: Sodium Fluoride with K2EDTA / Potassium Oxalate.
Used for glucose determination. Compared with potassium oxalate, EDTA provides better sample quality with results in less than 24 hours.
cfDNA Preservation for Fetal Screening
Xinle cfDNA BCT stabilizes circulating cell-free DNA in maternal blood, enabling accurate non-invasive screening of fetal chromosomal and genetic conditions via high-throughput sequencing.
Xinle cfDNA BCT
Xinle cfDNA BCT effectively inhibits nuclease activity to prevent the degradation of cell-free DNA (cfDNA). At the same time, it stabilizes blood cells and prevents genomic DNA contamination caused by cellular lysis, ensuring the integrity and accuracy of plasma cfDNA during long-term room temperature transportation.
It provides stable preservation of circulating cell-free DNA and meets the requirements of high-throughput sequencing applications.
Six NIPT Screening Applications
Comprehensive cfDNA-based screening coverage from common trisomies to fetal RhD genotyping and paternity analysis.
Trisomy 21/18/13 Screening
Xinle cfDNA BCT ensures accurate NGS-based detection of chromosomal aneuploidies involving chromosomes 21, 18, and 13.
Sex Chromosome Aneuploidy Detection
Xinle cfDNA BCT enables reliable detection of sex chromosome abnormalities, including Turner syndrome (45,X), Triple X syndrome (47,XXX), Klinefelter syndrome (47,XXY), and Jacobs syndrome (47,XYY).
Microdeletion Syndrome Detection
Xinle cfDNA BCT ensures accurate detection of microdeletion syndromes, including DiGeorge syndrome (22q11.2 deletion), Prader–Willi syndrome (15q11.2-q13 deletion), and Cri-du-chat syndrome (5p15.3 deletion).
Fetal RhD Genotyping
Xinle cfDNA BCT supports accurate fetal RhD blood group identification, providing reliable guidance for Rh immunoglobulin (RhIg) prophylactic treatment.
Non-Invasive Prenatal Paternity Testing
Xinle cfDNA BCT is suitable for non-invasive prenatal paternity testing based on STR analysis directly from maternal peripheral blood samples.
Potential Maternal Malignancy Identification
Xinle cfDNA BCT supports the incidental detection of potential maternal malignancies during routine NIPT screening.
NIPT Product Selection Guide
Purpose-built cfDNA collection tubes for non-invasive prenatal testing and downstream NGS library preparation.
NIPT Collection Product Matrix
cfDNA BCT Performance Benchmarks
Key stability and performance indicators validated by independent clinical laboratory studies.
From Blood Draw to NGS Library
An optimized NIPT sample processing workflow with four key steps ensures high-quality cfDNA preservation for downstream NGS library preparation and accurate bioinformatic analysis.
Venous Blood Collection
Collect peripheral blood into the Xinle cfDNA BCT using a 21G–23G blood collection needle.
Gentle Mixing & Room Temperature Transportation
After blood collection, gently invert the tube 5–8 times. The tube can preserve samples for up to 7 days at 10–30°C without requiring cold-chain transportation.
Plasma Separation by Centrifugation
Centrifuge at 1500–2300 × g for 10 minutes to separate plasma.
cfDNA Extraction & NGS Library Preparation
Compatible with next-generation sequencing platforms including Illumina VeriSeq, Ion Torrent, and BGI. The tube is fully compatible with automated laboratory workflows.
Preservation Solutions for Tumor Screening
Xinle cfDNA BCT, cfRNA BCT, and Urine DNA Preservation Tubes effectively inhibit nuclease activity, prevent background nucleic acid release caused by blood cell lysis, and maintain circulating tumor DNA/RNA stability during room-temperature transport for reliable tumor genetic mutation detection.
1. cfDNA / cfRNA Preservation for Tumor Screening
Xinle cfDNA BCT and cfRNA BCT effectively inhibit nuclease activity, prevent the release of background nucleic acids caused by blood cell lysis, and maintain the stability of circulating tumor DNA/RNA during long-term room temperature transportation, ensuring reliable detection of tumor genetic mutations.
Four Core Blood-Based Liquid Biopsy Applications
Comprehensive stabilization covering ctDNA mutation analysis, ctRNA/miRNA profiling, MRD tracking, and intact CTC preservation.
I. Circulating Tumor DNA (ctDNA) Detection
ctDNA is released into the bloodstream through apoptosis or necrosis of solid tumor cells and carries tumor-specific genetic mutation information. It is one of the key targets in liquid biopsy applications.
Specially designed stabilizing reagent system inhibits plasma nuclease activity while preventing white blood cell lysis and non-target gDNA release, maintaining ctDNA stability at room temp for up to 7 days.
Preservation and transportation of cell-free DNA from blood samples for tumor screening and molecular analysis.
II. Circulating Tumor RNA (ctRNA / miRNA) Detection
The expression profiles of microRNA (miRNA) and mRNA undergo significant changes during tumor development and progression, making them promising biomarkers for early cancer screening and tumor classification.
cfRNA Blood Collection Tubes inhibit plasma RNase activity, stabilize circulating cell-free RNA, and prevent the release of background RNA and RNase caused by blood cell lysis.
Collection, preservation, and transportation of circulating RNA from blood samples for tumor screening.
III. Minimal Residual Disease (MRD) Monitoring
Ultra-sensitive ctDNA detection is widely used for postoperative recurrence risk assessment and treatment strategy optimization.
cfDNA Blood Collection Tubes provide stable preservation of low-abundance ctDNA, supporting accurate MRD detection and longitudinal monitoring.
IV. Circulating Tumor Cell (CTC) Detection
Xinle cfDNA BCT and cfRNA BCT help maintain cell membrane integrity and prevent rare circulating tumor cells from breaking down after blood collection.
By preserving tumor cell surface-specific antigens, these tubes provide reliable support for downstream circulating tumor cell isolation and detection.
2. Consumables for Non-Invasive Urinary System Tumor Screening
Tumor DNA from epithelial tumors of the urinary system, including bladder cancer, kidney cancer, and prostate cancer, can be released into urine. Urine DNA Preservation Tubes inhibit nuclease activity in urine samples and prevent the release of genomic DNA from nucleated exfoliated cells.
Main Application: Preservation and transportation of urine DNA samples for early diagnosis and molecular testing of urinary system diseases.
Tumor Screening Product Matrix
Specially formulated blood and urine collection consumables for liquid biopsy, ctDNA/cfRNA preservation, and urinary tumor diagnostics.
Tumor Screening Product Matrix
Product Performance Highlights
Sample Collection Workflow
Step-by-step procedures for blood and urine specimen collection, stabilization, transportation, and molecular analysis.
Blood Samples (ctDNA / ctRNA / Whole Blood DNA Testing)
Blood Collection
Collect peripheral blood using a 21G–23G needle into cfDNA/cfRNA/whole blood DNA collection tubes.
Gentle Inversion
Immediately invert the tube gently 5–8 times to ensure complete mixing with the stabilizer.
Room Temp Transport
Transport at room temperature (6–37°C) without requiring cold-chain transportation.
Plasma Separation
Centrifuge to separate plasma at 1,500–2,300 × g for 10 minutes.
Molecular Analysis
Proceed directly with cfDNA/cfRNA extraction and downstream NGS or PCR analysis.
Urine Samples (Urinary System Tumor Detection)
Urine Collection
Collect 30–80 mL of midstream urine into a sterile urine container.
Sample Transfer
Transfer the urine sample into the Urine DNA Preservation Tube.
Gentle Inversion
Immediately invert the tube gently 5–10 times for proper mixing.
Room Temp Transport
Transport at room temperature without cold-chain requirements.
Downstream Testing
Perform urine cfDNA extraction and downstream molecular testing.
Blood-Related Testing for Blood Banking & Transfusion Medicine
Engineering advanced vacuum blood collection systems designed for transfusion safety, whole-blood cell preservation, HLA tissue typing, CDC crossmatching, and high-sensitivity nucleic acid testing (NAT) for transfusion-transmitted infections.
Xinle ACD & PPT Specimen Collection Systems
Xinle's ACD blood preservation tube effectively prevents coagulation, maintains blood cell viability and antigen integrity, and supports stable preservation of whole-blood specimens at 2–8 °C for up to 21 days.
Xinle's PPT tube effectively prevents coagulation and facilitates plasma separation. The product is sterile, pyrogen-free, DNase-free, and RNase-free, and does not interfere with nucleic acid amplification, providing transfusion-related molecular diagnostics with high-quality qualified specimens.
Transfusion Diagnostic & Screening Applications
Targeted testing protocols for donor-recipient histocompatibility, crossmatching, and viral safety screening.
1. HLA Genotyping (Tissue Typing)
Used to extract genomic DNA from patients or donors and identify HLA-A, -B, -C, -DR, and -DQ loci by molecular diagnostic methods.
2. CDC Crossmatch
Complement-Dependent Cytotoxicity Crossmatch (CDC Crossmatch). ACD tubes preserve cell viability and have minimal effect on complement activity, making them well suited to sample collection for CDC crossmatching.
3. Transfusion-Transmitted Infection NAT
Testing for transfusion-transmitted infections primarily includes HBV, HCV, HIV, and Treponema pallidum (syphilis). Nucleic acid testing (NAT) offers high sensitivity and accurate results.
Blood Banking & Transfusion Product Matrix
Specialized collection tubes formulated for long-term whole-blood storage, cell stability, and molecular NAT assays.
Blood Banking Collection Product Matrix
Blood Banking Performance Benchmarks
Validated performance specifications ensuring specimen integrity and analytical accuracy.
Step-by-Step Sample Collection Workflow
Standardized operational protocol for blood sample collection, mixing, temperature-controlled transport, and downstream handling.
Whole Blood Collection
Collect whole blood into the collection tube using the matching blood collection needle.
Immediate Gentle Inversion
Immediately and gently invert the tube 5–8 times after collection to mix thoroughly.
Blood Bank Transport
Transport to the blood bank at 2–8 °C or room temperature.
Processing & Testing
Centrifuge to separate plasma or use whole blood directly for testing.
PBMC Isolation & Immunogenomics Diagnostics
Xinle's Cell Preparation Tube (CPT) combines anticoagulant with density gradient media and gel barrier for one-step isolation of viable mononuclear cells (PBMCs), advancing immunogenetics, flow cytometry, minimal residual disease (MRD), and molecular diagnostics.
Xinle Cell Preparation Tube (CPT)
Xinle's Cell Preparation Tube (CPT) is used to collect venous blood specimens and prepare mononuclear cell suspensions. It enables one-step centrifugation to isolate peripheral blood mononuclear cells (PBMCs) while maintaining high cell viability. The isolated mononuclear cells are suitable for molecular diagnostics platforms, flow cytometry platforms, and cell culture.
By integrating polyester gel separation barrier with density gradient media in a single closed blood collection system, CPT eliminates manual layer blood piping, reduces contamination risk, and standardizes pre-analytical cell harvesting for clinical laboratories.
Six Primary Immunological & Genetic Diagnostic Applications
Targeted workflows supporting immune cell functional assays, leukemia marker screening, HLA tissue typing, and precision pharmacogenomics.
1. Lymphocyte Immune Function Testing
Flow cytometry for lymphocyte subset analysis (CD3+, CD4+, CD8+, B cells, NK cells) and absolute enumeration in clinical immune function assessment.
2. Leukemia Marker & MRD Testing
High-sensitivity molecular detection of leukemia-associated genetic markers for Minimal Residual Disease (MRD) monitoring post-chemotherapy.
3. HLA Genotyping (Tissue Typing)
Human Leukocyte Antigen (HLA) genotyping extracting high-purity genomic DNA for allele typing across HLA-A, -B, -C, -DR, and -DQ loci.
4. Immune Repertoire Sequencing
Deep sequencing of T-cell receptor (TCR) and B-cell receptor (BCR) immune repertoires to evaluate immune dynamics and disease progression.
5. Cell Culture & Functional Assays
Preserves high mononuclear cell viability for ex vivo cell culture, ELISPOT, cytokine release assays, and functional cellular immunity monitoring.
6. Pharmacogenomics Testing
Targeted genotyping of key drug-hypersensitivity genetic markers (e.g., HLA-B*5701, HLA-B*1502) to guide individualized precision therapy.
Immunology & Genetic Testing Product Matrix
Specialized cell preparation and molecular collection tubes for immunogenomics laboratories.
Immunology Collection Product Matrix
CPT Mononuclear Cell Isolation Metrics
Validated performance benchmarks for immunogenetics reference laboratories and clinical trial sites.
CPT PBMC Isolation Workflow
Standardized operational protocol ensuring optimum mononuclear cell yield and viability.
Venous Blood Collection
Draw venous blood into CPT tube up to the recommended fill line using standard venipuncture techniques.
Immediate Gentle Inversion
Gently invert the tube 8–10 times immediately after collection to mix blood thoroughly with anticoagulant.
One-Step Centrifugation
Centrifuge at 1500–1800g for 15–20 minutes at room temperature within 2 hours of specimen collection.
PBMC Harvesting & Testing
Aspirate the distinct mononuclear cell layer above the gel for flow cytometry, molecular diagnostic assays, or cell culture.
Pyrogen-Free Blood Collection Tubes for G Test / GM Test
Xinle's pyrogen-free blood collection tubes are engineered with strict control of product endotoxin levels. Serum tubes are optimized for collecting specimens for G tests and GM tests, preventing false-positive interference and supporting combined multi-marker fungal pathogen diagnostics.
Xinle Pyrogen-Free Blood Collection Systems
Xinle's pyrogen-free blood collection tubes are manufactured with stringent endotoxin control (<0.005 EU/mL). By preventing exogenous bacterial endotoxin contamination, these tubes protect the Factor G enzymatic activation pathway in Limulus amebocyte lysate (LAL) reagents, avoiding false-positive interference during clinical fungal screening.
Because clinical fungal infections are complex, multiple testing methods are usually used in combination to investigate pathogens one by one. Xinle provides multiple pyrogen-free configurations (Plain, Clot Activator, Separating Gel + Clot Activator) enabling single-tube high-yield serum harvesting for combined G-test and GM-test diagnostic panels.
Core Diagnostic Applications for Invasive Fungal Infection
Dual biomarker testing protocols for early screening and precise identification of deep fungal pathogens.
1. G Test — (1→3)-β-D-Glucan Testing
(1→3)-β-D-glucan is a key fungal cell wall component released into blood during infection. Using Xinle pyrogen-free tubes prevents bacterial endotoxin from accidentally activating the Factor C pathway in Limulus lysate (LAL) reagents, eliminating false positives and ensuring true Factor G pathway sensitivity for fungal detection.
2. Combined G Test & GM Test
The Galactomannan antigen test (GM test) detects early Aspergillus infection. Combining GM testing with G testing significantly improves invasive fungal diagnostic performance. High-quality serum from a single Xinle pyrogen-free tube supports multiple tests, providing strong guidance for clinical antifungal therapy.
Pyrogen-Free Product Matrix
Certified pyrogen-free collection tubes designed for high-sensitivity G test / GM test serum preparation.
Pyrogen-Free Collection Product Matrix
Pyrogen-Free Quality & Endotoxin Control Standards
Strictly validated performance metrics for clinical fungal diagnostics and critical care units.
Standard Blood Collection Procedure for G Test / GM Test
Standardized operational protocol to guarantee pyrogen-free serum quality from venipuncture to testing.
Venous Blood Draw
Use a pyrogen-free blood collection tube to collect peripheral venous blood.
Indicated Fill Volume
Collect the blood strictly according to the indicated collection volume line.
Immediate Gentle Inversion
Immediately and gently invert the tube 5–8 times after collection.
Room Temp Clotting
Allow sample to stand at room temp for 30–60 mins until fully clotted.
Serum Centrifugation
Centrifuge at recommended speed to separate clean serum.
G / GM Testing
Perform testing immediately or store the sample as required.
Pyrogen-Free Specimen Collection for LAL Factor C Assay
Bacterial endotoxin is the most critical pyrogen in clinical diagnostics. Xinle's pyrogen-free blood collection tubes maintain extremely low endotoxin levels, protecting the Limulus amebocyte lysate (LAL) Factor C enzymatic activation pathway from sample contamination and false-positive interference.
Xinle Pyrogen-Free Blood Collection System for BET
Detecting bacterial endotoxin in blood specimens is an important means of assessing infection. The Limulus amebocyte lysate (LAL) method relies on the Factor C enzymatic pathway, specifically activated by bacterial endotoxin. Xinle's pyrogen-free collection tubes eliminate exogenous endotoxin contamination at the source, preventing false-positive results.
Medical devices with endotoxin levels below specified limits qualify as pyrogen-free. Xinle offers Clot Activator, Sodium Heparin, Gel + Clot Activator, and Plain Tube configurations, providing certified pyrogen-free collection for serum and plasma endotoxin assays and pyrogen-sensitive research.
Core Diagnostic & Research Applications for Bacterial Endotoxin
Targeted specimen collection for endotoxemia screening, Gram-negative sepsis workup, and pyrogen-sensitive immunological studies.
1. Bacterial Endotoxin Testing (BET)
Quantitative clinical testing for Gram-negative bacterial infection and systemic endotoxemia, utilizing pyrogen-free collection tubes to prevent sample contamination from causing false-positive LAL reactions.
2. Auxiliary Sepsis Diagnosis
Rapid diagnostic aid for patients clinically suspected of Gram-negative bacterial sepsis, bacteremia, or severe acute endotoxemia in ICU and critical care settings.
3. Pyrogen-Sensitive Research
In clinical research assessing febrile reactions, cytokine release profiles, and immune activation pathways, pyrogen-free tubes eliminate exogenous pyrogen noise right from the sample collection source.
Pyrogen-Free Product Matrix for Endotoxin Testing
Certified pyrogen-free collection tubes designed for high-sensitivity LAL Factor C endotoxin assays.
Endotoxin Collection Product Matrix
Pyrogen-Free Standards & Quality Metrics
Strict quality controls meeting BET regulatory limits for clinical diagnostics and pyrogen-sensitive studies.
Standard Blood Collection Procedure for BET Testing
Standardized operational protocol to guarantee pyrogen-free specimen quality from venipuncture to testing.
Venous Blood Draw
Use a pyrogen-free blood collection tube to collect peripheral venous blood.
Indicated Fill Volume
Collect the blood strictly according to the indicated collection volume line.
Immediate Gentle Inversion
Immediately and gently invert the tube 5–8 times after collection.
Controlled Standing
Allow sample to stand at room temperature per specific testing method requirements.
Centrifugation Separation
Centrifuge at recommended speed to separate clean serum or plasma.
Bacterial Endotoxin Testing
Perform BET testing immediately or store the sample as required by assay IFU.
Tuberculosis Testing
Xinle provides specialized blood collection solutions for tuberculosis IGRA testing. CPT tubes enable one-step PBMC isolation, while pyrogen-free sodium-heparin tubes ensure whole-blood stimulation without endotoxin interference for stable and reliable results.
Interferon-Gamma Release Assay (IGRA) Mechanism
Individuals infected with Mycobacterium tuberculosis (MTB) have memory lymphocytes that specifically recognize tuberculosis-specific antigens. When exposed again to tuberculosis-specific antigens in vitro, these cells produce large amounts of interferon-gamma (IFN-γ). Measuring IFN-γ indicates whether MTB infection is present.
Heparin-anticoagulated blood is typically used with a negative control tube (N tube), positive control tube (P tube), and specific stimulation antigen tube (T tube). Whole-blood specimens are incubated to stimulate peripheral blood T-cell responses before plasma centrifugation and IFN-γ measurement.
Testing Items
Core diagnostic testing applications and immunological assessments for tuberculosis screening.
TB Infection Testing (IGRA)
Interferon-gamma release assay (IGRA) for detecting Mycobacterium tuberculosis infection in clinical and health screening populations.
T-Cell Immune Response
Assessment of tuberculosis-specific T-cell cellular immune responses for accurate differentiation of infection status.
Recommended Products & Performance
High-purity collection consumables specifically designed for IGRA whole-blood and PBMC isolation assays.
Tuberculosis IGRA Product Matrix
Sample Collection Procedure
Standardized operational workflows for CPT tube PBMC isolation and Pyrogen-Free Sodium-Heparin whole-blood IGRA testing.
IGRA Testing (CPT Tube)
Blood Draw
Collect whole blood into the CPT tube (sodium-heparin anticoagulated type).
Inversion
Immediately and gently invert 8–10 times.
Stand Vertically
Allow the tube to stand vertically at room temperature.
Centrifugation
Centrifuge — isolate PBMCs using the one-step centrifugation method.
PBMC Harvest
Collect the PBMC layer.
Assay Protocol
Proceed according to the reagent kit instructions.
IGRA Testing (Pyrogen-Free Heparin Blood Collection Tube)
Venous Draw
Use a pyrogen-free heparin blood collection tube to collect peripheral venous blood.
Exact Volume
Collect the blood strictly according to the indicated collection volume.
Gentle Inversion
Immediately and gently invert 5–8 times after collection.
Room Temp Stand
Allow the sample to stand at room temperature for 30–60 minutes.
Reagent Incubation
Proceed according to the testing reagent instructions.