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Sample Preservation Solution (Tissue, Cell & Nucleic Acid Stability)

XINLE Sample Preservation Solution is a specialized, ready-to-use clinical reagent formulated for the ambient stabilization and long-term preservation of fresh human tissue, biopsy specimens, exfoliated cells, and bodily fluids. Compounded with high-efficiency protease inhibitors, nuclease blockers, and pathogen-inactivating agents, this solution locks cell morphology and preserves high-molecular-weight DNA/RNA integrity across multiple temperature zones (18–25°C, 2–8°C, -80°C) without cold-chain logistics.

Product Overview

Manufactured under strict ISO 13485 quality management systems, the XINLE Sample Preservation Solution delivers a standardized, cold-chain-free pre-analytical solution for pathology laboratories, biobanks, and molecular diagnostic centers.

Fresh clinical biopsies, surgical tissues, and cytological fluids undergo rapid cellular autolysis, protein degradation, and enzymatic nucleic acid fragmentation within minutes of excision. Our advanced multi-component formula rapidly permeates dense tissue blocks and cell suspensions, simultaneously inactivating endogenous proteases, DNases, and RNases. It securely preserves cellular architecture for histopathological sectioning while safeguarding genomic DNA and total RNA for downstream next-generation sequencing (NGS).

Regulatory Notice: Clinical Laboratory Reagent for Pathological, Cytological & Molecular Specimen Stabilization.

Key Features & Biological Advantages

  • Multi-Enzyme Suppression (Proteases & Nucleases): Rapidly permeates tissue and cell membranes, actively suppressing endogenous proteases, DNase, and RNase activities to prevent specimen autolysis and nucleic acid breakdown.
  • Pathogen Inactivation & Biosafety: Chemically inactivates pathogenic viruses, bacteria, and infectious agents in clinical specimens, significantly reducing biohazard exposure risks for transport logistics and laboratory personnel.
  • Cold-Chain-Free Multi-Temperature Stability: 
    37°C: Stable for 2–3 Days (withstands extreme transit heat)
    18–25°C (Room Temperature): Stable for 1 Week
    2–8°C (Refrigerated): Stable for 1–2 Months
    -20°C to -80°C (Ultra-Low Freezing): Stable for Long-Term Biobanking
  • Repeated Freeze-Thaw Resilience: Preserved tissue and cellular samples maintain structural stability and nucleic acid yield across multiple freeze-thaw cycles without significant degradation.
  • Preserves Histology & Cellular Morphology: Mild buffer system maintains cell dispersal and cellular morphology, perfectly supporting routine hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and flow cytometry.
  • Ready-to-Use One-Step Immersion: Requires no tedious on-site dilution or pre-treatment; simply submerge fresh specimens directly into the solution.

Clinical, Pathological & Molecular Applications

Sample Preservation Solution is the universal preservation medium across clinical pathology, diagnostic oncology, and translational research:

  • Fresh Surgical Tissue & Biopsy Preservation: Immediate immersion of fresh surgical resections, endoscopic biopsies, and core needle biopsies, slowing apoptosis and preserving primary tissue viability.
  • Histopathology & Immunohistochemistry (IHC): Preserving tissue blocks for paraffin embedding, microtome sectioning, and diagnostic antibody staining.
  • Cytopathological Analysis: Fixation and morphological preservation of fine-needle aspiration (FNA) puncture cells, exfoliated cervical cells, sputum, and pleural effusions.
  • Nucleic Acid Extraction & Genomic Sequencing: Direct extraction of high-yield, high-purity DNA and RNA for PCR, quantitative qPCR, target sequencing, and NGS library prep.
  • Infectious Disease Swabs & Lavage Fluids: Stabilizing nasopharyngeal swabs, sputum, serum/plasma, and bronchoalveolar lavage fluid (BALF).
  • Biobanking & Translational Research: Standardized ambient collection for multi-center clinical trials and tissue repositories.

Product Specifications & Packaging

Product NameAvailable Bottle VolumesShelf LifePackaging ConfigurationStorage Temperature
Sample Preservation Solution1.8 mL, 5 mL, 10 mL, 20 mL, 100 mL, 200 mL, 500 mL1 Year (12 Months)50 Bottles per CartonRoom Temperature (18–25°C)

Formulation: Multi-component Enzyme Inhibitors, Pathogen Inactivators, and Nucleic Acid Stabilizers.

How to Use Sample Preservation Solution

Follow these standardized operational guidelines for optimal specimen preservation:

  1. Immediate Immersion: Immerse fresh tissue blocks (recommended thickness ≤5 mm for rapid penetration) or cytological swabs/fluids directly into the preservation solution immediately after excision or sampling.
  2. Ensure Full Submersion: Ensure the volume ratio of preservation solution to tissue specimen is at least 5:1 to 10:1 to guarantee complete immersion and rapid enzyme inactivation.
  3. Cap Tightening: Fasten the bottle cap tightly to prevent leakage and evaporation.
  4. Ambient Transportation: Store and ship the sealed bottles at ambient room temperature (18–25°C) directly to the pathology or molecular testing laboratory.

Frequently Asked Questions (FAQ)

A: This solution is widely compatible with a comprehensive variety of biological samples, including:

  • Fresh surgical tissue and needle biopsy specimens;
  • Exfoliated cells and fine-needle puncture (FNA) cells;
  • Nasopharyngeal swabs, oropharyngeal swabs, and sputum;
  • Serum, plasma, and whole blood fractions;
  • Bronchoalveolar lavage fluid (BALF) and body cavity effusions.

A: The stabilization formulation provides robust, multi-temperature sample preservation windows:

  • At 37°C: Stable for 2–3 days;
  • At Room Temperature (18–25°C): Stable for 1 week;
  • At 2–8°C (Refrigeration): Stable for 1–2 months;
  • At -20°C or -80°C: Supports long-term cryogenic biobanking without loss of nucleic acid integrity.

A: No. This product is strictly for single-use only. Reusing solution from a previously opened container introduces cross-contamination, alters chemical inhibitor concentrations, and invalidates downstream pathological and molecular test results. Always check container seal integrity prior to use.

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